Wednesday, April 12, 2006

JMR, Jerschow, selection of ordered 23Na signals via central transition

Journal of Magnetic Resonance
Volume 180, Issue 1 , May 2006, Pages 105-109

Selective detection of ordered sodium signals via the central transition

Jennifer Choy, Wen Ling and Alexej Jerschow

Chemistry Department, New York University, New York, NY 10003, USA


Given the correlation between the concentrations of ordered 23Na and the onset of tissue disorders, the ability to select the signal from ordered 23Na over that of free 23Na is of particular importance and can greatly enhance the potential of 23Na-MRI as a diagnostic tool. Here, we describe a simple method that selectively detects the central transition of ordered sodium while minimizing the signal from free sodium. Our method relies upon the influence of the quadrupolar interaction on nutation frequencies and may also benefit solid-state imaging experiments. Both a liquid crystalline environment and a cartilage sample are used to demonstrate a clean separation between anisotropic and isotropic regions in the experiments.

Keywords: Nutation; Double-quantum filter; Sodium-MRI; Ordered sodium; Quadrupolar coupling; Cartilage imaging

No comments: