Rapid Analysis of Organic Compounds by Proton-Detected Heteronuclear Correlation NMR Spectroscopy with 40-kHz Magic-Angle Spinning
Donghua H. Zhou, Chad M. Rienstra
Angwandte (2008), Article ASAP
Summary:
High-sensitivity proton detection enabled acquisition of well-resolved two-dimensional spectra in only 30 min for less than 5 mg of organic compounds at natural abundance. Besides faster resonance assignment, rapid analysis of crystal polymorphism, molecular dynamics, and H-bonding is possible. This method is applicable to both pure and dosage forms of solid pharmaceuticals, such as ibuprofen
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