J. Am. Chem. Soc., 2009, 131 (14), pp 5014–5015

A Microfluidic High-Resolution NMR Flow Probe

Jacob Bart†, Ard J. Kolkman‡, Anna Jo Oosthoek-de Vries‡, Kaspar Koch‡, Pieter J. Nieuwland‡, Hans (J. W. G.) Janssen‡, Jan (P. J. M.) van Bentum‡, Kirsten A. M. Ampt‡, Floris P. J. T. Rutjes‡, Sybren S. Wijmenga‡, Han (J. G. E.) Gardeniers† and Arno P. M. Kentgens*‡

Abstract
A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid.